00 Copertina 7.0:cop

00 Copertina N1 2011 7.0:cop

Design of a product-focused customer-oriented process

In an increasingly dynamic world where both needs and technologies are changing rapidly, there is a requirement for whole-life Customer-oriented Processes (CoPs) for software systems and software development. In the pursuit of delivering 'fit for purpose' systems, the design of a CoP requires an holistic approach to understanding, engineering, managing and evolving the system and software needs...

A038 copertina

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Nef-Induced CD4 Degradation A Diacidic-Based Motif in Nef Functions as a Lysosomal Targeting Signal through the Binding of β-COP in Endosomes

The Nef protein of primate lentiviruses downregulates the cell surface expression of CD4 through a two-step process. First, Nef connects the cytoplasmic tail of CD4 with adaptor protein complexes (AP), thereby inducing the formation of CD4-specific clathrin-coated pits that rapidly endocytose the viral receptor. Second, Nef targets internalized CD4 molecules for degradation. Here we show that N...

Molecular Mechanisms of Endocytosis

that is needed to change membrane shape and to form a vesicle is very simple. These studies are in line with previous genetic studies that have identified a limited Howard Riezman,* Philip G. Woodman,† Gerrit van Meer,‡ and Mark Marsh§ *Biozentrum of the University of Basel CH-4056 Basel number of proteins that are required for COP-II-coated Switzerland vesicle formation from the ER. The functi...